by Nicholas Mitsakos | Book Chapter, China, Globalization, Innovation, Public Policy, Science, Technology, Transformative businesses, Writing and Podcasts
The US’s competitive advantage was developing the world’s best educational system, initiating innovative research and development, welcoming the world’s best students to thrive in an unrestricted environment, and accessing unique forms of capital for entrepreneurial ideas. The unique environment that combined academia and entrepreneurship, as seen at places like Bell Labs and Fairchild Semiconductor, was the spark that ignited Silicon Valley, the Life Sciences Corridor, the Innovation District, and the Research Triangle, among others, creating an unprecedented entrepreneurial environment and economic engine. This drove economic growth, disruptive innovation, and greater prosperity. This created a virtuous cycle that enhanced national wealth and economic opportunity. We are undermining all these advantages. The next 20 years will be defined by choices made today. Talent, energy, and technological innovation build the foundation for prosperity. Undermine them, and you guarantee decline.
by Nicholas Mitsakos | Artificial Intelligence, Book Chapter, Globalization, irrationality, Science, Technology, Transformative businesses, Writing and Podcasts
We are on the precipice of technological innovations that could potentially disrupt humanity, but they will not happen overnight, nor will they be out of our control. We have the time and hopefully the perspective to make wise choices.
It’s happened before.
A little over 100 years ago, and within a few decades, the automobile, the airplane, the telephone, and the electrical grid remade the physical and social fabric of life. For the first time, distances collapsed. Cities and homes glowed with electric light. Factories ran with continuous power. Communication traveled instantly across continents. People traveled unimaginable distances in hours rather than weeks or months.
What had been science fiction for centuries became everyday reality, and people felt both awe and dislocation. We can learn from the past, as the scale of disruption from that era was likely far greater than what we are experiencing today.
The Total Perspective Vortex is a form of torture because the truth of one’s insignificance is unbearable. Perhaps that truth is found in the disruptive innovations we admire and fear, the humanity that may be lost in this sea of technological innovation, and our anxiety about our own irrelevance.
We have a deeper responsibility. It’s happened before; perhaps humankind can make better use of the new era of disruptive innovation and our expanding powers more wisely.
In other words, get a perspective.
by Nicholas Mitsakos | Book Chapter, Green Energy, Science, Technology, Transformative businesses, Writing and Podcasts
A new generation of clean, reliable, and flexible energy technologies, including, geothermal and advanced nuclear energy, is emerging. The story is no longer about clean and renewable energy. Solar and wind have their place, but capital investment and policy incentives are now focused on reliable, low-cost, controllable, domestic energy. For the first time in years, the policy, market, and demand signals are aligned in favor of a portfolio of solutions that are testing the edges of technology and are no longer narrow niches.
by Nicholas Mitsakos | Artificial Intelligence, Biotechnology, Book Chapter, Science, Technology, Transformative businesses, Writing and Podcasts
With better models, more effective benchmarks, and a framework for constant improvement, now is the time to focus AI on complex, innovative, and transformational tasks. Essentially, AI and models should focus on hard tech. Hard tech refers to businesses rooted in advanced engineering and scientific innovation, often involving the development of physical products or systems that address complex challenges. Beyond drones, robots, and AI-driven hardware, the following are prominent examples of hard tech opportunities across industries. AI-driven hard tech is creating new business models and industries, such as personalized medicine, autonomous logistics, smart infrastructure, and agentic AI platforms that autonomously manage complex operations, reshaping the competitive landscape and unlocking new avenues for value creation. As a result, businesses and professionals who embrace interdisciplinary skills and continuous learning will thrive in the hard tech ecosystem.
by Nicholas Mitsakos | Artificial Intelligence, Book Chapter, China, Economy, Globalization, Public Policy, Science, Taiwan, Technology, Transformative businesses, Writing and Podcasts
The convergence of volatile geopolitics fragmented and unpredictable markets, disruptive technologies, and unique opportunities. Understanding geopolitical issues, developing innovative and insightful investment strategies, and navigating political and economic volatility are now essential to achieving investment success.
by Nicholas Mitsakos | Innovation, Science, Writing and Podcasts
Many experts are exaggerating artificial intelligence’s power and peril. Most public commentary, ranging from politicians to prominent technologists, says AI – more precisely, AGI – is close to surpassing human intelligence. The significant risk is that artificial intelligence will supplant human beings. This speculation even comes from Geoffrey Hinton, a Nobel prize-winning AI pioneer. AI models are useful, but, as Yann LeCun, Meta’s AI head, says, they are far from rivaling a house cat’s intelligence, let alone humans. The talk that AI will become so powerful that it poses an existential threat to human beings is nonsense. AI is a powerful tool and is becoming enormously important in all aspects of the economy. But AGI, malicious or otherwise, will not happen anytime soon.
by Nicholas Mitsakos | Artificial Intelligence, Book Chapter, Innovation, Science, Technology, Transformative businesses, Writing and Podcasts
AI is not a data problem; it is a cognitive architecture problem. Data and computing power will become insurmountable hurdles for transformer-based models. A new generation of AI models requires fundamental breakthroughs. Large data models can’t learn, transfer knowledge or understanding, understand the relevance, or use analogous learning to transfer that relevance and predict. Current AI models require massive and increasing data and learn from reinforcement. This cannot scale and is massively inefficient. Real learning based on cognitive architecture, focused dynamic data, and referential data sets is a better solution. This is closer to real human learning, more effective and efficient, and offers a significantly better solution. Understanding the natural learning process — referential and analogous data, categorization, transferring and building upon that data, and creating knowledge applicable to new situations — learning builds upon itself and is exponentially effective. That is the real AI solution.
by Nicholas Mitsakos | Artificial Intelligence, Biotechnology, Book Chapter, Digital Assets, Innovation, Investments, Science, Technology, Writing and Podcasts
Global technological transformation and disruptive technologies create extraordinary opportunities – and magnified risks. Headline-grabbing hyperbole dominates each news cycle, and some forecasts and bewildering futuristic projections can mostly be dismissed. However, meaningful substance and catalytic disruptive change are permeating all industries.
A context to understand these developments – a broader, methodical, and disciplined way to think about disruption and transformation- shows that extraordinary opportunities on a highly competitive global scale are emerging.
Artificial intelligence and AI-generated tools, digital assets, blockchain-based businesses, gene editing, and DNA sequencing profoundly impact the world’s most important industries. New technological innovations and platforms enable unprecedented disruption to all business and economic models.
by Nicholas Mitsakos | Artificial Intelligence, Book, Book Chapter, Innovation, Science, Technology, Transformative businesses, Writing and Podcasts
Artificial intelligence is poised to significantly impact various fields and activities, transforming how we approach creativity, professional activities, science, and many more domains. Disruption will accelerate the development of new innovative businesses and strategies in finance, medicine, data management, systems engineering, materials science, art, and other industries. AI’s impact will be profound and multifaceted, driving innovation and efficiency and posing challenges regarding ethics, job displacement, and new skills and regulations. As AI continues to evolve, its integration into these areas will likely shape the future of human society in significant ways.
by Nicholas Mitsakos | Artificial Intelligence, Biotechnology, Book Chapter, crispr, drug discovery, Health Care, Innovation, Science, Writing and Podcasts
The first gene-edited approved drug (treating sickle cell anemia) is the first commercial rewriting of human genomes. Is this a new “Golden Age” for medicine? There is great promise, and the potential to treat unmet medical needs, scale dramatic innovations to commercial applications, and transform life sciences is enormous. Since every medicine is an intersection of scientific, technical, and clinical understanding, many new treatments are suddenly arriving because of the convergence of dramatic advancements in science, technical knowledge, and clinical results. Modern medicine is witnessing a transformative era of groundbreaking innovations and technological advancements. We are witnessing a renaissance in drug treatment driven by innovations in immunotherapy, weight management, vaccine development, gene editing, and AI. These advances reshape medical treatments and fundamentally alter our approach to health and disease. As these technologies mature and their applications broaden, the future of medicine holds unprecedented potential for improving human health and longevity. A golden age – with a bit of hype.
by Nicholas Mitsakos | Artificial Intelligence, Book Chapter, drug discovery, Green Energy, Innovation, Public Policy, Science, Technology, Transformative businesses, Writing and Podcasts
The era of artificial intelligence is here, and it’s generating despair and fear over the loss of control and the worry that artificial intelligence is about to unleash killer robots and enslave humanity. Perhaps…or, something else. Artificial intelligence will improve lives and generate greater access to education, improve healthcare, and advance climate science. Among many other improvements, AI’s benefits greatly outweigh its costs. AI has its costs since everything comes with a price (there are always both sides to the ledger), but the extraordinary benefits that artificial intelligence can unleash are worth the effort. Don’t slow down, pause, or restrict research, development, and AI applications. Prometheus gave the world fire and while we can still cause great harm, it was among the single greatest advancements for humankind. Artificial intelligence can be the same thing for our modern-day recipients of fire from the gods. But, we can’t be naïve. We can still burn the earth down if we are not careful. AI will not destroy the world – and is more likely to save it. I’s trajectory points towards a future where it not only enhances technological capabilities but also enriches human lives. Its evolving role will be characterized by a synergy between human and artificial intelligence, propelling societal progress and opening new frontiers of innovation and discovery is not just a technological advancement; it’s a catalyst for a new era of human endeavor. Its impact is vast, touching every aspect of our lives and work. As AI continues to evolve, its role in shaping our society and driving innovation will only become more significant, opening new horizons for growth, creativity, and human potential.
by Nicholas Mitsakos | Book, Financial Technology, Innovation, Science, Technology, Transformative businesses, Writing and Podcasts
Cryptocurrencies soar in value, plunge, hit new highs, are written off, rebound, and hit new highs again, and the cycle repeats. We should be terrified. Over the last five years, cryptocurrencies such as Bitcoin and Ether have outperformed the overall market. However, can the general trend of outperformance last, or will these digital assets drop over 90% like some of its other crypto brethren? Is there a sustainable performance that creates the foundation for either a new currency or a valuable asset class? Probably not. Forces that drive these eye-watering returns seem to be the same as those that drove the social media-driven insanity behind meme stocks such as GameStop. We are seeing social media mobs controlling demand to a limited supply, creating price spikes that look attractive to any speculative investor. Unfortunately, demand can dry up quickly and the price subsequently falls through the floor. Financial markets ruthlessly sort nonsense from substance. Volatility and existential threats have been brutal and extreme for digital assets and the reckoning for crypto has been predicted for some time. However, digital assets are not on their way to history’s dustbin. Reality is more nuanced, and I try to provide a more detailed analysis since a broad brush hardly seems appropriate. The weakest and craziest portions of the crypto world have been exposed as nothing more than silliness. But some valuable components remain resilient and offer tremendous opportunity. I will explore these in detail. There is more cause for optimism than pessimism among the best and the brightest. We will explore these opportunities while harshly dismissing the hype and silliness – avoid the terror of worthless market.
