by Nicholas Mitsakos | Book Chapter, China, Globalization, Innovation, Public Policy, Science, Technology, Transformative businesses, Writing and Podcasts
The US’s competitive advantage was developing the world’s best educational system, initiating innovative research and development, welcoming the world’s best students to thrive in an unrestricted environment, and accessing unique forms of capital for entrepreneurial ideas. The unique environment that combined academia and entrepreneurship, as seen at places like Bell Labs and Fairchild Semiconductor, was the spark that ignited Silicon Valley, the Life Sciences Corridor, the Innovation District, and the Research Triangle, among others, creating an unprecedented entrepreneurial environment and economic engine. This drove economic growth, disruptive innovation, and greater prosperity. This created a virtuous cycle that enhanced national wealth and economic opportunity. We are undermining all these advantages. The next 20 years will be defined by choices made today. Talent, energy, and technological innovation build the foundation for prosperity. Undermine them, and you guarantee decline.
by Nicholas Mitsakos | Book Chapter, China, Globalization, Innovation, Taiwan, Technology, Writing and Podcasts
The sustainability of advanced technologies, unique manufacturing capabilities, global access, and robust supply chains is currently dependent on ill-defined, reckless, and volatile political and economic strategies. Ignoring the reality of the situation and hoping things will eventually work out isn’t a good plan. For decades, the world has relied on Taiwan Semiconductor (TSMC) to produce the most advanced chips, powering everything from smartphones to artificial intelligence. This dependence has created an unprecedented vulnerability: a single geopolitical flashpoint controls the lifeblood of the global digital economy. The challenges of advanced semiconductor technologies and manufacturing are among the most pressing and significant issues of this generation. The U.S. must acknowledge that a world dominated by a single supplier is unsustainable. It must invest not only in fabs but also in intellectual capital, allied coordination, and long-term technological leaps. There is no guarantee of success. The rivalry with China will intensify, and Taiwan will remain a flashpoint. But inaction is the greater risk. Hope may provide comfort, but only strategy, investment, and execution will ensure resilience. Hope is not a plan.
by Nicholas Mitsakos | Artificial Intelligence, Book Chapter, Globalization, irrationality, Science, Technology, Transformative businesses, Writing and Podcasts
We are on the precipice of technological innovations that could potentially disrupt humanity, but they will not happen overnight, nor will they be out of our control. We have the time and hopefully the perspective to make wise choices.
It’s happened before.
A little over 100 years ago, and within a few decades, the automobile, the airplane, the telephone, and the electrical grid remade the physical and social fabric of life. For the first time, distances collapsed. Cities and homes glowed with electric light. Factories ran with continuous power. Communication traveled instantly across continents. People traveled unimaginable distances in hours rather than weeks or months.
What had been science fiction for centuries became everyday reality, and people felt both awe and dislocation. We can learn from the past, as the scale of disruption from that era was likely far greater than what we are experiencing today.
The Total Perspective Vortex is a form of torture because the truth of one’s insignificance is unbearable. Perhaps that truth is found in the disruptive innovations we admire and fear, the humanity that may be lost in this sea of technological innovation, and our anxiety about our own irrelevance.
We have a deeper responsibility. It’s happened before; perhaps humankind can make better use of the new era of disruptive innovation and our expanding powers more wisely.
In other words, get a perspective.
by Nicholas Mitsakos | China, Economy, Globalization, Public Policy, Technology, Trade, Writing and Podcasts
The United States and China play global economic and political chess games. There are numerous moves and defensive and offensive strategies, not only for trade but also for energy and natural resources (rare earths, among the most recent sources of discord), geopolitics (Russia, Ukraine, Iran, and the Middle East generally), technology (Taiwan and AI), and global economic supremacy. It’s a long list, but China and the US drive the outcomes. Let’s be clear, Apple designed the iPhone, but it was China’s manufacturing workforce that made it a global phenomenon. China’s millions of engineers and factory workers accumulate practical hands-on knowledge from experience that cannot be easily transferred. This sustainable advantage creates new industries, including electric vehicles, drones, and alternative energy, with world-leading expertise. In the meantime, America’s engineering expertise has been hollowed out. It is naïve to imagine wrestling China back to the past. The project, now, is to contest its moral vision of the future. Connected, collaborative engagement is the only practical way. China has come a long way, and its trajectory cannot be ignored or dismissed. The U.S. and China will be much better off from this more enlightened, realistic perspective.
by Nicholas Mitsakos | Book Chapter, Green Energy, Science, Technology, Transformative businesses, Writing and Podcasts
A new generation of clean, reliable, and flexible energy technologies, including, geothermal and advanced nuclear energy, is emerging. The story is no longer about clean and renewable energy. Solar and wind have their place, but capital investment and policy incentives are now focused on reliable, low-cost, controllable, domestic energy. For the first time in years, the policy, market, and demand signals are aligned in favor of a portfolio of solutions that are testing the edges of technology and are no longer narrow niches.
by Nicholas Mitsakos | Artificial Intelligence, China, Innovation, Public Policy, Technology, Writing and Podcasts
The US is still ahead of China in artificial intelligence. However, perhaps the key to China’s success lies in its open-source model ecosystem, combined with aggressive development in semiconductor design and manufacturing. Our world is not static, and the world of artificial intelligence is where momentum matters. AI can potentially be transformative, and although current geopolitical rhetoric does not allow for cooperation or collaboration, AI progress and innovation are ultimately a global collaborative effort. If done correctly, it benefits many more and it does not come at the expense of any one nation. That should be the AI Action Plan.
by Nicholas Mitsakos | Currency, Digital Assets, Financial Technology, Globalization, Innovation, Writing and Podcasts
The U.S. Treasury is likely to need to borrow approximately $15 trillion over the next decade. As incredible as that seems, the U.S. Treasury cares about the price of that debt, and therefore, since they are the seller, they need to attract as many buyers as possible to keep the cost of that debt as low as possible. Basic supply and demand at work. Reliable treasury bond buyers are pulling back, primarily China and, to a certain degree, Japan. The Genius Act permits private entities to issue their own stablecoins, provided they are fully backed by U.S. treasuries. That will open up a new set of investors for the U.S. Treasury as it issues its required bonds. On the one hand, it’s an interesting solution because the Treasury can access an expanding market that exists outside the banking system. Expect to see much more international capital flows in US dollars, as well as significantly increased shadow banking among large US-based corporate entities that engage in business with each other and internationally.
by Nicholas Mitsakos | Artificial Intelligence, Book Chapter, Globalization, Technology, Transformative businesses, Writing and Podcasts
Artificial intelligence is driving technological disruption and economic transformation. It is a unique opportunity and, like PCs, the Internet, mobile, and cloud computing before it, AI is driving a new supercycle. Unlike previous technological revolutions, the current transformation is exponential, creating new industries and markets and impacting existing economic structures, costs, distribution, and employment. While productivity and economic growth are expected to surge, the most significant opportunity arises for capital owners, and therefore, investors. AI will be the most significant economic catalyst of the 21st century, fundamentally altering how we work, innovate, and create value.
by Nicholas Mitsakos | Artificial Intelligence, Biotechnology, Book Chapter, Science, Technology, Transformative businesses, Writing and Podcasts
With better models, more effective benchmarks, and a framework for constant improvement, now is the time to focus AI on complex, innovative, and transformational tasks. Essentially, AI and models should focus on hard tech. Hard tech refers to businesses rooted in advanced engineering and scientific innovation, often involving the development of physical products or systems that address complex challenges. Beyond drones, robots, and AI-driven hardware, the following are prominent examples of hard tech opportunities across industries. AI-driven hard tech is creating new business models and industries, such as personalized medicine, autonomous logistics, smart infrastructure, and agentic AI platforms that autonomously manage complex operations, reshaping the competitive landscape and unlocking new avenues for value creation. As a result, businesses and professionals who embrace interdisciplinary skills and continuous learning will thrive in the hard tech ecosystem.
by Nicholas Mitsakos | Artificial Intelligence, Book Chapter, Technology, Transformative businesses, Writing and Podcasts
So far, we’ve attempted to answer that question through benchmarks. These give models a fixed set of questions to answer and grade them on how many they get right. But just like exams, these benchmarks don’t always reflect deeper abilities. Lately, it seems as if a new AI model is released every week, and each time a company introduces one, it comes with fresh scores showing it surpassing the capabilities of its predecessors. AI research is a hypercompetitive infinite game. An infinite game is open-ended—the goal is to keep playing. However, in AI, a dominant player often produces a significant result, triggering a wave of follow-up papers that chase the same narrow topic. This race-to-publish culture puts enormous pressure on researchers, rewarding speed over depth and short-term wins over long-term insight. If academia chooses to play a finite game, it will lose.
This “finite vs. infinite game” framework also applies to benchmarks. So, do we have a truly comprehensive scoreboard for evaluating the true quality of a model? Not really. Many dimensions—social, emotional, interdisciplinary—still evade assessment. But the wave of new benchmarks hints at a shift. As the field evolves, a bit of skepticism is probably healthy.
by Nicholas Mitsakos | Artificial Intelligence, Biotechnology, Book, Writing and Podcasts
Uncertainty and decisions. This book helps readers better understand a situation (What), determine why it’s important (So What), and decide what to do next (Now What).The world is uncertain, and all decisions are made in an uncertain environment with unpredictable outcomes. This challenge transcends disciplines, industries, and professions. An increasingly complex modern world shaped by artificial intelligence, geopolitical instability, data overload, and rapidly evolving technology can overwhelm decision-makers who rely on outdated ways of thinking. Uncertainty is unavoidable. It is not the enemy. It can be navigated with structure and discipline. Critical thinking, multiple perspectives, and decision tools help prioritize, forecast, and adapt decisions, but cannot dictate outcomes. “Decision Intelligence” is vital because it combines data, models, and human judgment, all augmented with new technologies, especially artificial intelligence. Better decisions come from clarity, not certainty. This is the foundation of resilience, agility, and better decision-making during volatile, unpredictable, and transformative environments. It’s not simply a matter of having a formula. Uncertain circumstances are not simple mathematical problems but require systematic and structured thinking. Understanding these structures and the motivations behind the various approaches will be essential. This approach is more of a way to think about thinking. As Einstein said, “Give me 60 minutes to solve a problem, and I will spend 55 minutes defining it. Then the solution will be obvious. ”This book is about those 55 minutes.
by Nicholas Mitsakos | Book Chapter, China, Globalization, Public Policy, Taiwan, Technology, Trade, uncertainty, Writing and Podcasts
The global investment landscape has reached a structural inflection point. Geopolitical realignments, industrial policy, and national security concerns are reshaping the era of frictionless globalization. At the center of this transformation is the intensifying strategic competition between the United States and China. The US is acting belligerently toward China in trade negotiations, threatening exorbitant tariff rates and trying to build walls around China’s international trade activity. All this may be a high-volume attempt to bring China to the table to strike a better trade arrangement. While this tactic is unprecedented, we may only be in the third inning of a nine-inning game. The current geopolitical and economic transition is both a challenge and a multi-decade opportunity. Capital will increasingly flow to regions that demonstrate policy consistency, innovation capacity, and demographic vibrancy. Strategic sectors such as AI, defense, semiconductors, energy, digital infrastructure, and cybersecurity will drive private and public investment. Embracing this new reality of regional diversification, thematic depth, and geopolitical foresight will position participants to thrive. As multipolarity replaces global uniformity, success lies with active, strategic alignment with the forces shaping the next economic era.
