by Nicholas Mitsakos | Book Chapter, China, Economy, Globalization, Investment Principles, Writing and Podcasts
The “Thucydides Trap” occurs when a rising nation-state—for the Greek historian Thucydides, it was Athens—must eventually have a violent confrontation with the existing dominant nation-state—Sparta in his time. It is a zero-sum game where there can be only one dominant nation-state as the eventual winner, and it is usually assumed that the rising nation-state will outdo the dominant nation-state resolved only by military conflict.The United States and China are today’s Sparta and Athens. For several decades, their geopolitical relationship has been fundamentally based on collaboration and healthy competition, raising the bar for both countries. Now, it is turning into discordant competition, trade restrictions, and embargoes. The combined benefits of global collaboration and competitiveness, not trade restraint, will only enhance the benefits for the United States and China. The government creates friction and potential conflict, which is the biggest reason we fall into the Thucydides Trap. If appropriate, oversight, sensible regulation, and enforceable trade agreements do not interfere with fair competition and collaboration. There is no “Trap” to avoid. The sooner China and the US realize this, the better off each country (and the world) will be.
by Nicholas Mitsakos | Artificial Intelligence, Book Chapter, China, Globalization, Innovation, Public Policy, Transformative businesses, Writing and Podcasts
Significant VC activity and AI development opportunities are emerging in China. DeepSeek is the Vanguard of innovation from the artificial intelligence “moonshot” encouraged by the Chinese government. Not only will we see ongoing developments from Alibaba and Tencent, but there will also be a layer of elite AI companies at the forefront of China’s AI sector. US sanctions and restrictions have only increased innovation and groundbreaking AI development activity in China. Those sanctions will amount to nothing and encourage accelerated advancement.
by Nicholas Mitsakos | Artificial Intelligence, Book Chapter, Innovation, Science, Technology, Transformative businesses, Writing and Podcasts
AI is not a data problem; it is a cognitive architecture problem. Data and computing power will become insurmountable hurdles for transformer-based models. A new generation of AI models requires fundamental breakthroughs. Large data models can’t learn, transfer knowledge or understanding, understand the relevance, or use analogous learning to transfer that relevance and predict. Current AI models require massive and increasing data and learn from reinforcement. This cannot scale and is massively inefficient. Real learning based on cognitive architecture, focused dynamic data, and referential data sets is a better solution. This is closer to real human learning, more effective and efficient, and offers a significantly better solution. Understanding the natural learning process — referential and analogous data, categorization, transferring and building upon that data, and creating knowledge applicable to new situations — learning builds upon itself and is exponentially effective. That is the real AI solution.
by Nicholas Mitsakos | Book Chapter, Globalization, Innovation, Public Policy, Technology, Writing and Podcasts
The paranoia is building. From the CHIPS Act to proposals for absurdly high tariffs (60% on goods from China isn’t going to help anyone) to banning TikTok, the world is on the verge of reversing decades of progress and exchanging real progress for delusionary gains.
Efforts to localize production and economic development with vast government subsidies are being proposed or enacted in the United States, the EU, China, India, and any other economic center that can think of it.
Hiding behind walls has never worked and makes life worse for everyone.
by Nicholas Mitsakos | Artificial Intelligence, Biotechnology, Book Chapter, Digital Assets, Innovation, Investments, Science, Technology, Writing and Podcasts
Global technological transformation and disruptive technologies create extraordinary opportunities – and magnified risks. Headline-grabbing hyperbole dominates each news cycle, and some forecasts and bewildering futuristic projections can mostly be dismissed. However, meaningful substance and catalytic disruptive change are permeating all industries.
A context to understand these developments – a broader, methodical, and disciplined way to think about disruption and transformation- shows that extraordinary opportunities on a highly competitive global scale are emerging.
Artificial intelligence and AI-generated tools, digital assets, blockchain-based businesses, gene editing, and DNA sequencing profoundly impact the world’s most important industries. New technological innovations and platforms enable unprecedented disruption to all business and economic models.
by Nicholas Mitsakos | Artificial Intelligence, Book, Book Chapter, Innovation, Science, Technology, Transformative businesses, Writing and Podcasts
Artificial intelligence is poised to significantly impact various fields and activities, transforming how we approach creativity, professional activities, science, and many more domains. Disruption will accelerate the development of new innovative businesses and strategies in finance, medicine, data management, systems engineering, materials science, art, and other industries. AI’s impact will be profound and multifaceted, driving innovation and efficiency and posing challenges regarding ethics, job displacement, and new skills and regulations. As AI continues to evolve, its integration into these areas will likely shape the future of human society in significant ways.
by Nicholas Mitsakos | Artificial Intelligence, Biotechnology, Book Chapter, crispr, drug discovery, Health Care, Innovation, Science, Writing and Podcasts
The first gene-edited approved drug (treating sickle cell anemia) is the first commercial rewriting of human genomes. Is this a new “Golden Age” for medicine? There is great promise, and the potential to treat unmet medical needs, scale dramatic innovations to commercial applications, and transform life sciences is enormous. Since every medicine is an intersection of scientific, technical, and clinical understanding, many new treatments are suddenly arriving because of the convergence of dramatic advancements in science, technical knowledge, and clinical results. Modern medicine is witnessing a transformative era of groundbreaking innovations and technological advancements. We are witnessing a renaissance in drug treatment driven by innovations in immunotherapy, weight management, vaccine development, gene editing, and AI. These advances reshape medical treatments and fundamentally alter our approach to health and disease. As these technologies mature and their applications broaden, the future of medicine holds unprecedented potential for improving human health and longevity. A golden age – with a bit of hype.
by Nicholas Mitsakos | Artificial Intelligence, Book Chapter, drug discovery, Green Energy, Innovation, Public Policy, Science, Technology, Transformative businesses, Writing and Podcasts
The era of artificial intelligence is here, and it’s generating despair and fear over the loss of control and the worry that artificial intelligence is about to unleash killer robots and enslave humanity. Perhaps…or, something else. Artificial intelligence will improve lives and generate greater access to education, improve healthcare, and advance climate science. Among many other improvements, AI’s benefits greatly outweigh its costs. AI has its costs since everything comes with a price (there are always both sides to the ledger), but the extraordinary benefits that artificial intelligence can unleash are worth the effort. Don’t slow down, pause, or restrict research, development, and AI applications. Prometheus gave the world fire and while we can still cause great harm, it was among the single greatest advancements for humankind. Artificial intelligence can be the same thing for our modern-day recipients of fire from the gods. But, we can’t be naïve. We can still burn the earth down if we are not careful. AI will not destroy the world – and is more likely to save it. I’s trajectory points towards a future where it not only enhances technological capabilities but also enriches human lives. Its evolving role will be characterized by a synergy between human and artificial intelligence, propelling societal progress and opening new frontiers of innovation and discovery is not just a technological advancement; it’s a catalyst for a new era of human endeavor. Its impact is vast, touching every aspect of our lives and work. As AI continues to evolve, its role in shaping our society and driving innovation will only become more significant, opening new horizons for growth, creativity, and human potential.
by Nicholas Mitsakos | Book Chapter, China, Economy, Globalization, Public Policy, Trade, Transformative businesses, Writing and Podcasts
Isolationism, fragmentation, and pessimism always fail. Globalization has been everyone’s favorite punching bag for a while. It is hard to feel optimistic about its prospects. However, globalization has a better future. If you are a fan of globalization, cooperation, and comparative advantage, the last decade has been extremely challenging. Ten years ago was a time of optimism on a global scale. However, economic and geopolitical forces have combined to add friction and fragmentation to global exchange. The benefits are now even greater and with everyone’s self-interest and mutual benefit, this geopolitical stalemate will pass – more quickly than is commonly thought today. Cooperation, integration, and mutual benefit win in the end. It is a time to be optimistic once again.
by Nicholas Mitsakos | Artificial Intelligence, Biotechnology, Book Chapter, drug discovery, Green Energy, Health Care, Innovation, Public Policy, Science, Technology, Transformative businesses, Writing and Podcasts
Our most intractable problems cannot be solved with behavior modification, conservation, or our existing technology, regardless of its advanced or widespread applications. Only new knowledge creating innovative solutions can address our most intractable problems. This can only be achieved through basic scientific discoveries and then combining these discoveries with enterprise-based innovation, commercial discipline, and competition. Innovation, creativity, and competitive dynamics create the most effective innovations, the best solutions, and the most sustainable companies. Developing the best public policy as well as the best structure to enable innovative and creative solutions, as well as the economic incentive to scale these opportunities and make them economically sustainable. Central planning, bureaucratic industrial policy, government-led economic management, and dictatorial focus have always failed, and always will.
by Nicholas Mitsakos | Book, Book Chapter, Economy, Innovation, Investment Principles, Public Policy, Science, Technology, Trade, Writing and Podcasts
Zero-sum thinking has begun. Despite comparative advantage, mutual cooperation, and specialization proving indisputably more beneficial than any other approach to economic interaction, this ideal is under threat. Rules and norms for economic integration lifted hundreds of millions of people out of poverty, created an order-of-magnitude increase in the average wealth of the Western population, and benefited countless hundreds of millions enabling a way of life otherwise unimaginable post-World War II. Now that system is under threat as developed countries subsidize alternative energy, attract manufacturing via expensive subsidies, and restrict the flow of goods and capital. Mutual benefit is out; national gain is now the highest priority. In other words, stupidity and zero-sum thinking have taken over. A handful of bureaucrats, regardless of how brilliant each may be, can never equal the mind of the market. Management and control usually spell disaster eventually. Managed focus on technological development for products and services the central government believes have greater substantial benefit to the overall society may not be calamitous, but the law of unintended consequences has not been repealed. It will be inefficient, substandard, and create potentially dangerous side effects. Innovation, creative freedom, and unstructured thought are essential components to the development of any technology of substance and disruptive benefit.
by Nicholas Mitsakos | Book Chapter, Innovation, Science, Technology, uncertainty, Writing and Podcasts
In his preamble to “The Theory of Relativity,” Einstein implored his reader to, “set aside your proud certainty” because he was about to present something quite revolutionary, iconoclastic, and, as he discovered for many years after publication, challenging to be broadly accepted. Of course, his insights would be vindicated, and would soon be considered one of the leading minds of the 20th century, and perhaps one of the great minds in scientific history. Einstein knew things that everybody else was ignorant of and was ignorant of things that everybody else knew. That was probably the key to his great thinking – he assumed no knowledge and didn’t confuse himself with the trivial or unimportant. Always explore, race to keep up, clear the field, and let other vibrant minds pass. It is the spark of human creation, analysis, and understanding that gives us a glimpse of nature’s fundamental beauty. We only touch a small fraction, and our hardest work and most diligent thinking expose a little bit more – and that is one of humankind’s most worthwhile pursuits. Set aside proud certainty; be indifferent to your failings and the cacophony of critics. See, question, verify, and question again.
